Growth control: Invertebrate insulin surprises!

被引:60
作者
Leevers, SJ
机构
[1] Ludwig Inst Canc Res, London W1W 7BS, England
[2] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
关键词
D O I
10.1016/S0960-9822(01)00107-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent work on Drosophila has provided new insights into how insulin signalling - conserved in mammals, flies and worms - regulates growth and cell division during development. Invertebrates have been found to possess more insulin-like ligands than predicted, some of which behave as receptor antagonists.
引用
收藏
页码:R209 / R212
页数:4
相关论文
共 15 条
[1]   CONTROL OF LARVAL DEVELOPMENT BY CHEMOSENSORY NEURONS IN CAENORHABDITIS-ELEGANS [J].
BARGMANN, CI ;
HORVITZ, HR .
SCIENCE, 1991, 251 (4998) :1243-1246
[2]   An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control [J].
Brogiolo, W ;
Stocker, H ;
Ikeya, T ;
Rintelen, F ;
Fernandez, R ;
Hafen, E .
CURRENT BIOLOGY, 2001, 11 (04) :213-221
[3]   The Drosophila insulin receptor is required for normal growth [J].
Chen, C ;
Jack, J ;
Garofalo, RS .
ENDOCRINOLOGY, 1996, 137 (03) :846-856
[4]  
Coelho CM, 2000, J CELL SCI, V113, P2927
[5]   Size control in animal development [J].
Conlon, I ;
Raff, M .
CELL, 1999, 96 (02) :235-244
[6]   New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling [J].
Duret, L ;
Guex, N ;
Peitsch, MC ;
Bairoch, A .
GENOME RESEARCH, 1998, 8 (04) :348-353
[7]   From small flies come big discoveries about size control [J].
Edgar, BA .
NATURE CELL BIOLOGY, 1999, 1 (08) :E191-E193
[8]   THE DROSOPHILA INSULIN-RECEPTOR HOMOLOG - A GENE ESSENTIAL FOR EMBRYONIC-DEVELOPMENT ENCODES 2 RECEPTOR ISOFORMS WITH DIFFERENT SIGNALING POTENTIAL [J].
FERNANDEZ, R ;
TABARINI, D ;
AZPIAZU, N ;
FRASCH, M ;
SCHLESSINGER, J .
EMBO JOURNAL, 1995, 14 (14) :3373-3384
[9]   Genetic pathways that regulate ageing in model organisms [J].
Guarente, L ;
Kenyon, C .
NATURE, 2000, 408 (6809) :255-262
[10]   Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans [J].
Kawano, T ;
Ito, Y ;
Ishiguro, M ;
Takuwa, K ;
Nakajima, T ;
Kimura, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 273 (02) :431-436