Cell cycle regulators and their abnormalities in breast cancer

被引：35

作者：

Fernández, PL ^{[1
]}

Jares, P ^{[1
]}

Rey, MJ ^{[1
]}

Campo, E ^{[1
]}

Cardesa, A ^{[1
]}

机构：

[1] Univ Barcelona, IDIBAPS, Hosp Clin Barcelona,Dept Anat Pathol, Inst Invest Biomed August Pi & Sunyer, E-08036 Barcelona, Spain

来源：

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 1998年 / 51卷 / 06期

关键词：

cell cycle regulators; breast cancer; cyclins; cyclin dependent kinases; retinoblastoma gene product;

D O I：

10.1136/mp.51.6.305

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

One of the main properties of cancer cells is their increased and deregulated proliferative activity. It is now well known that abnormalities in many positive and negative modulators of the cell cycle are frequent in many cancer types, including breast carcinomas. Abnormalities such as defective function of the retinoblastoma gene and cyclin-dependent kinase inhibitors (for example, p16, p21, and p27), as well as upregulation of cyclins, are often seen in breast tumours. These abnormalities are sometimes coincidental, and newly described interplays between them suggest the existence of a complex regulatory web in the cell cycle.

引用

页码：305 / 309

页数：5