Micro/nanostructured polymeric systems for biomedical and pharmaceutical applications

被引：80

作者：

Chiellini, Federica ^{[1
]}

Piras, Anna Maria ^{[1
]}

Errico, Cesare ^{[1
]}

Chiellini, Emo ^{[1
]}

机构：

[1] Univ Pisa, Dept Chem & Ind Chem, UdR INSTM, Lab Bioact Polymer Mat Biomed Environm Applicat, I-56010 Pisa, Italy

来源：

NANOMEDICINE | 2008年 / 3卷 / 03期

关键词：

biocompatible polymers; biomedical applications; drug delivery; nanomedicine; polymeric nanoparticles;

D O I：

10.2217/17435889.3.3.367

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This review provides an outline of the polymeric micro/nanostructured advanced systems that are suited for the controlled and targeted administration of, specifically, nonconventional drugs. The contribution of new trends in drug-delivery technology is focused on two major parts, dealing with brief surveys of: the biodegradable/bioerodible polymeric systems used in the formulation of micro/nanoparticles and techniques used in the preparation of micro/nanoparticles for their biomedical application in cancer treatment specifically, in inflammation pathologies, as oxygen carriers (blood substitutes) and in tissue-engineering practice. A small discussion of the future perspectives of the described systems is also given.

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页码：367 / 393

页数：27

相关论文

共 240 条

[1] Novel cationic pentablock copolymers as non-viral vectors for gene therapy [J].

Agarwal, A ;

Unfer, R ;

Mallapragada, SK .

JOURNAL OF CONTROLLED RELEASE, 2005, 103 (01) :245-258

[2] Recent advances on chitosan-based micro- and nanoparticles in drug delivery [J].

Agnihotri, SA ;

Mallikarjuna, NN ;

Aminabhavi, TM .

JOURNAL OF CONTROLLED RELEASE, 2004, 100 (01) :5-28

[3] Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs: Complexation and stabilization of insulin [J].

Akiyoshi, K ;

Kobayashi, S ;

Shichibe, S ;

Mix, D ;

Baudys, M ;

Kim, SW ;

Sunamoto, J .

JOURNAL OF CONTROLLED RELEASE, 1998, 54 (03) :313-320

[4] Controlled association of amphiphilic polymers in water:: Thermosensitive nanoparticles formed by self-assembly of hydrophobically modified pullulans and poly(N-isopropylacrylamides) [J].

Akiyoshi, K ;

Kang, EC ;

Kurumada, S ;

Sunamoto, J ;

Principi, T ;

Winnik, FM .

MACROMOLECULES, 2000, 33 (09) :3244-3249

[5]

Albertsson AC, 2002, ADV POLYM SCI, V157, P1

[6] Factors affecting the degradation and drug-release mechanism of poly(lactic acid) and poly[(lactic acid)-co-(glycolic acid)] [J].

Alexis, F .

POLYMER INTERNATIONAL, 2005, 54 (01) :36-46

[7] Polycaprolactone-b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone [J].

Allen, C ;

Han, JN ;

Yu, YS ;

Maysinger, D ;

Eisenberg, A .

JOURNAL OF CONTROLLED RELEASE, 2000, 63 (03) :275-286

[8] Solid lipid nanoparticles as a drug delivery system for peptides and proteins [J].

Almeida, Antonio J. ;

Souto, Eliana .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (06) :478-490

[9] SPECIFIC REACTIONS OF POLYELECTROLYTES WITH THE SURFACES OF NORMAL AND TUMOUR CELLS [J].

AMBROSE, EJ ;

EASTY, DM ;

JONES, PCT .

BRITISH JOURNAL OF CANCER, 1958, 12 (03) :439-447

[10] Nanoparticles with specific bioadhesive properties to circumvent the pre-systemic degradation of fluorinated pyrimidines [J].

Arbós, P ;

Campanero, MA ;

Arangoa, MA ;

Irache, JM .

JOURNAL OF CONTROLLED RELEASE, 2004, 96 (01) :55-65

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