Age-related morphology trends of cortical sulci

被引：168

作者：

Kochunov, P

Mangin, JF

Coyle, T

Lancaster, J

Thompson, P

Rivière, D

Cointepas, Y

Règis, J

Schlosser, A

Royall, DR

Zilles, K

Mazziotta, J

Toga, A

Fox, PT

机构：

[1] Univ Texas, Hlth Sci Ctr, Res Imaging Ctr, San Antonio, TX 78284 USA

[2] CEA, Serv Hosp Frederic Joliot, F-91406 Orsay, France

[3] Univ Texas, Dept Psychol, San Antonio, TX 78285 USA

[4] Univ Calif Los Angeles, Sch Med, Dept Neurol, Brain Mapping Ctr, Los Angeles, CA 90024 USA

[5] CHU Timone, Serv Neurochirurg Fonct, Marseille, France

[6] SO HF Fredrikstad Hosp, Dept Neurol, Fredrikstad, Norway

[7] Univ Texas, Hlth Sci Ctr, Dept Psychiat, San Antonio, TX 78284 USA

[8] Univ Dusseldorf, C&O Vogt Brain Res Inst, Dusseldorf, Germany

[9] Res Ctr Juelich, Inst Med, Julich, Germany

来源：

HUMAN BRAIN MAPPING | 2005年 / 26卷 / 03期

关键词：

D O I：

10.1002/hbm.20198

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The age-related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20-82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high-resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age-related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (P < 0.05), with males showing more pronounced age-related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age related changes than sulcal structures in unimodal cortical areas (P < 0.05).

引用

页码：210 / 220

页数：11

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