Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders

被引：57

作者：

Neff, Frauke ^{[1
]}

Wei, Xing ^{[2
]}

Noelker, Carmen ^{[1
]}

Bacher, Michael ^{[1
]}

Du, Yansheng ^{[1
,2
]}

Dodel, Richard ^{[1
]}

机构：

[1] Univ Marburg, Dept Neurol, D-35039 Marburg, Germany

[2] Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46202 USA

来源：

AUTOIMMUNITY REVIEWS | 2008年 / 7卷 / 06期

关键词：

Parkinson's disease; Alzheimer's disease; Creutzfeld-Jakob disease; naturally occurring autoantibodies; immunotherapy;

D O I：

10.1016/j.autrev.2008.04.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Parkinson's disease, Alzheimer's disease and other neurodegenerative disorders share a common pathologic pathway with aggregation and deposition of misfolded proteins causing a disruption of particular neuronal networks. Several mechanisms have been implicated in the down-stream events following deposition of misfolded proteins including failure of cellular defenses among many others. Recently, naturally occurring autoantibodies against beta-amyloid and alpha-synuclein have been detected in healthy persons and altered levels in patients were associated with particular neurodegenerative disorders. In this review the current knowledge on the role of naturally occurring autoantibodies is discussed in respect to neurodegenerative disorders. (C) 2008 Published by Elsevier B.V.

引用

收藏

页码：501 / 507

页数：7

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