The calcitonin gene-related peptide (CGRP) antagonist CGRP8-37 blocks vasodilatation in inflamed rat skin:: involvement of adrenomedullin in addition to CGRP

被引：15

作者：

Chu, DQ

Legon, S

Smith, DM

Costa, SKP

Cuttitta, F

Brain, SD

机构：

[1] Kings Coll London, Ctr Cardiovasc Biol & Med, London SE1 1UL, England

[2] Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Metab Med, London W12 0NN, England

[3] NCI, Cell & Canc Biol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

NEUROSCIENCE LETTERS | 2001年 / 310卷 / 2-3期

关键词：

adrenomedullin; calcitonin gene-related peptide; interleukin-1; beta; skin; microvasculature; vasodilator;

D O I：

10.1016/S0304-3940(01)02132-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuropeptide calcitonin gene-related peptide (CGRP) is a potent microvascular vasodilator in rat skin and effects are antagonised by CGRP(8-37), In this study, CGRP(8-37) significantly (P < 0.05) inhibited the time-dependent (3-5 h) increase in skin blood flow measured in the anaesthetised rat, after intradermal administration of the inflammatory cytokine interleukin-1 beta (3 pmol/site), indicating the involvement of CGRP1 receptors. The CGRP-related peptide adrenomedullin (ADM) is also a potent vasodilator in rat skin,with effects antagonised by CGRP(8-37) We show that ADM mRNA expression is increased in rat skin after treatment with IL-1 beta and that the IL-1p-induced blood flow is blocked by a selective ADM antibody (P < 0.05). Thus ADM is expressed locally in the inflamed cutaneous microvasculature where it can, in addition to, or as an alternative to CGRP, contribute to IL-1 beta -induced vasoactive effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：169 / 172

页数：4

共 18 条

[1] CALCITONIN GENE-RELATED PEPTIDE IS A POTENT VASODILATOR [J].