The α/β ratio for prostate cancer:: What is it, really?

被引:129
作者
Bentzen, SM [1 ]
Ritter, MA [1 ]
机构
[1] Univ Wisconsin, Sch Med, Dept Human Oncol, Madison, WI 53792 USA
关键词
D O I
10.1016/j.radonc.2005.06.009
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Two recent studies of fractionated external beam radiotherapy in early prostate cancer provide outcome data that allow a statistical estimation of the alpha/beta-ratio of the linear-quadratic model when combined with clinical data on the steepness of the dose-response curve. Results of the large randomized PR5 trial by the Ontario Clinical Oncology Group/National Cancer Institute of Canada yield an estimate of alpha/beta at 1.12 Gy with 95% confidence interval (-3.3, 5.6) Gy. A non-randomized study by Valdagni and colleagues of hyper-fractionation delivered BID versus conventional fractionation yields an alpha/beta-estimate of 8.3 Gy with 95% confidence interval (0.7, 16) Gy. Thus, the confidence interval of this latter study cannot exclude even very low values of alpha/beta. Furthermore, this point estimate may be an over-estimate if incomplete repair plays a role in the BID group of the Italian study. Taken together, the outcomes of these two studies still favor a high fractionation sensitivity of prostate cancer. (C) 2005 Published by Elsevier Ireland Ltd.
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页码:1 / 3
页数:3
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