Sox3 and sexual dysfunction:: it's in the head

被引：5

作者：

Camper, SA ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 03期

关键词：

D O I：

10.1038/ng0304-217

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Humans with mutations in SOX3 have panhypopituitarism, but the developmental mechanisms underlying this defect are unknown. Conditional disruption of Sox3 in mice now suggests that anterior pituitary development depends on Sox3 expression in the overlying neural ectoderm, which establishes midline structures and regulates production of inductive BMP and FGF signals.

引用

页码：217 / 219

页数：4

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