Receptor-Ck regulates giardia encystation process

The study addressed to resolve the mechanism involved in cholesterol-dependent regulation of giardia encystation process, revealed that (a) the trophozoites have the ability to express genes coding for receptor-C-k and sterol element binding protein (SREBP); (b) inhibition of cholesterol dependent activation of receptor-C-k results in the upregulation of CWP-1 gene expression leading to encystation process. Based upon these findings, we propose that receptor-C-k dependent signalling is responsible for the regulation of giardia encystation process by cholesterol.