SPECT imaging of the dopaminergic system in (premotor) Parkinson's disease

被引：44

作者：

Booij, Jan ^{[1
]}

Knol, Remco J. J. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1105 AZ Amsterdam, Netherlands

来源：

PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷

关键词：

(premotor) Parkinson's disease; dopamine transporter; SPECT; dopamine receptor; POSITRON-EMISSION-TOMOGRAPHY; D-2/3; RECEPTOR-BINDING; EARLY-STAGE; PROGRESSION; TRANSPORTER; LEVODOPA;

D O I：

10.1016/S1353-8020(08)70042-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In studies on (premotor) Parkinson's disease (PD), single photon emission computed tomography (SPECT) studies have focused on imaging of the presynaptic dopamine transporter (DAT) and postsynaptic dopamine D-2 receptors (D(2)Rs). Here we review the results of SPECT studies on the dopaminergic system in PD, with particular emphasis on: the accuracy of SPECT imaging of the dopaminergic system to detect alternations of the dopaminergic system in early PD, the diagnostic accuracy of DAT SPECT in PD, the contribution of DAT imaging to detect preclinical phases of PD, and the potential role of SPECT imaging to monitoring progression of dopaminergic degeneration in PD. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：S425 / S428

页数：4

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