Maintenance of homeostasis of endogenous ethanol as a method for the therapy of alcoholism

被引：4

作者：

Nikolaenko, VN ^{[1
]}

机构：

[1] VM Bekhterev Psychoneurol Res Inst, Dept Therapy Alcohol Dependence, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 03期

关键词：

alcoholism; alcohol dehydrogenase; ethanol homeostasis; emetine;

D O I：

10.1023/A:1017687012629

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

We propose a new method for the therapy of alcoholism based on maintenance of homeostasis of endogenous ethanol and inhibition of alcohol dehydrogenase with emetine. After the standard antialcohol therapy, activity of this enzyme remained high or even increased, and pathological alcohol addiction also increased. Emetine normalized activity of alcohol dehydrogenase and suppressed pathological alcohol addiction. After this therapy more than 50% patients achieved stable remissions from alcoholism over 1 year, which indicated high efficiency of the proposed method.

引用

页码：231 / 233

页数：3