Signaling intricacies take center stage in cancer cells

被引:50
作者
Kumar, R [1 ]
Hung, NC [1 ]
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA
关键词
D O I
10.1158/0008-5472.CAN-05-0189
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
After many years of productive study on the signaling networks, posttranslational regulatory control of effector molecules remains an intensely investigated and continuously evolving field of research to connect signaling with phenotypic changes. In recent years, there have been intriguing results on the interaction of critical molecules to control the growth of cancer cells. This review article will focus on two critical convergence signaling nodules, Akt and p21-activated kinase, two integral components of phenotypic signaling during tumorigenesis. Here we will summarize the recent findings on how these master signaling nodules regulate their targets and alter the subcellular localization of their effectors to control their functionality. Based on the laboratory advances in the Akt and p21-activated kinase signaling pathways, it is conceivable to start defining novel avenues to develop targeted anticancer therapies.
引用
收藏
页码:2511 / 2515
页数:5
相关论文
共 32 条
[1]   Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1 [J].
Adam, L ;
Vadlamudi, R ;
Mandal, M ;
Chernoff, J ;
Kumar, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (16) :12041-12050
[2]   Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase [J].
Adam, L ;
Vadlamudi, R ;
Kondapaka, SB ;
Chernoff, J ;
Mendelsohn, J ;
Kumar, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (43) :28238-28246
[3]   p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells [J].
Balasenthil, S ;
Sahin, AA ;
Barnes, CJ ;
Wang, RA ;
Pestell, RG ;
Vadlamudi, RK ;
Kumar, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (02) :1422-1428
[4]   Functional inactivation of a transcriptional corepressor by a signaling kinase [J].
Barnes, CJ ;
Vadlamudi, RK ;
Mishra, SK ;
Jacobson, RH ;
Li, F ;
Kumar, R .
NATURE STRUCTURAL BIOLOGY, 2003, 10 (08) :622-628
[5]   Breast cancer banishes p27 from nucleus [J].
Blain, SW ;
Massagué, J .
NATURE MEDICINE, 2002, 8 (10) :1076-1078
[6]   Biology of the p21-activated kinases [J].
Bokoch, GM .
ANNUAL REVIEW OF BIOCHEMISTRY, 2003, 72 :743-781
[7]   Cell cycle and death control: long live Forkheads [J].
Burgering, BMT ;
Kops, GJPL .
TRENDS IN BIOCHEMICAL SCIENCES, 2002, 27 (07) :352-360
[8]  
FAQUA S, 2004, CANCER RES, V64, P9199
[9]   p21-activated kinase signaling in breast cancer [J].
Gururaj, AE ;
Rayala, SK ;
Kumar, R .
BREAST CANCER RESEARCH, 2005, 7 (01) :5-12
[10]  
HARPER JW, 1993, CELL, V75, P805