Cadmium-induced liver, heart, and spleen lipid peroxidation in rats and protection by selenium

被引:44
作者
Jiin, SJ
Chern, CL
Sheu, JY
Lin, TH [1 ]
机构
[1] Tajen Inst Technol, Pingtung, Taiwan
[2] Kaohsiung Med Univ, Grad Inst Med, Kaohsiung, Taiwan
[3] Kaohsiung Med Univ, Sch Technol Med Sci, Kaohsiung, Taiwan
[4] Yuans Gen Hosp, Dept Med Res, Kaohsiung, Taiwan
关键词
cadmium chloride; lipid peroxidation; essential metal; liver; heart; spleen;
D O I
10.1385/BTER:78:1-3:219
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The purpose of this study was to evaluate the effects of cadmium induced peroxidative damage to rat liver, heart, and spleen. Sprague-Dawley rats were injected subcutaneously with a single dose of 25, 125, 500, or 1250 mug Cd/kg and evaluated 6, 12, 24, or 72 h later. Liver, heart, and spleen were analyzed for lipid peroxidation and Fe, Cu, Zn, Se, and Cd concentrations. Data showed that Cd produced enhanced lipid peroxidation in the liver, heart, and spleen. These Cd-induced changes were accompanied by a significant rise in liver, heart, and spleen Fe and Cu, and a fall in spleen Zn and liver, heart, and spleen Se. Concurrent treatment with Se and Cd reduced the Cd-induced alterations in liver, heart, and spleen peroxidation and essen tial metal levels. Data suggest that lipid peroxidation is associated with cadmium toxicity and that Se was found effective in preventing lipid peroxidation.
引用
收藏
页码:219 / 230
页数:12
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