Solubility study of nimodipine inclusion complexation with α- and β-cyclodextrin and some substituted cyclodextrins

被引：23

作者：

Kopecky, F ^{[1
]}

Kopecká, B ^{[1
]}

Kaclík, P ^{[1
]}

机构：

[1] Comenius Univ, Fac Pharm, SK-83232 Bratislava, Slovakia

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2001年 / 39卷 / 3-4期

关键词：

beta-cyclodextrins; alpha-cyclodextrins; hydroxypropyl-gamma-cyclodextrin; nimodipine; solubility; solubilization; inclusion complexes; binding constant;

D O I：

10.1023/A:1011155208944

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The solubility of nimodipine was measured in aqueous solutions of the following cyclodextrins: alpha -cyclodextrin (alpha -CD), hydroxypropyl-alpha -CD (HP-alpha -CD), beta -cyclodextrin (beta -CD), random substituted methyl-beta -CD (M-beta -CD), three hydroxypropyl-beta -CDs (HP-beta -CD) with mutually different average degree of substitution, and hydroxypropyl-gamma -cyclodextrin (HP-gamma -CD). From the determined linear solubility diagrams the values of the binding constant K-11 of the inclusion complexes of nimodipine with the respective CDs were evaluated. The beta -CDs efficiently solubilized sparingly soluble nimodipine, the highest value of K-11 was found for M-beta -CD (1680 M-1), followed by beta -CD (550 M-1) and HP-beta -CDs, where the higher degree of substitution lowered K-11. Only slight solubilization of nimodipine was observed in the solutions of the alpha -CDs and HP-gamma -CD.

引用

页码：215 / 217

页数：3

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