The multiple personalities of h-channels

被引：102

作者：

Santoro, B

Baram, TZ ^{[1
]}

机构：

[1] Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA

[2] Univ Calif Irvine, Irvine, CA 92697 USA

来源：

TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 10期

关键词：

D O I：

10.1016/j.tins.2003.08.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Concepts regarding the function of the hyperpolarization-activated current (I-h) in shaping the excitability of single cells and neuronal ensembles have been evolving rapidly following the recent cloning of genes that encode the underlying 'h-channels' - the HCN genes. This article reviews new information about the transcriptional regulation of these channels, highlighting novel studies that demonstrate short- and long-term modulation of HCN expression, and linking this modulation to mechanisms of neurological diseases.

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页码：550 / 554

页数：5

相关论文

共 36 条

[1] Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving roles in the developing rat hippocampus [J].

Bender, RA ;

Brewster, A ;

Santoro, B ;

Ludwig, A ;

Hofmann, F ;

Biel, M ;

Baram, TZ .

NEUROSCIENCE, 2001, 106 (04) :689-698

[2] Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus [J].

Bender, RA ;

Soleymani, SV ;

Brewster, AL ;

Nguyen, ST ;

Beck, H ;

Mathern, GW ;

Baram, TZ .

JOURNAL OF NEUROSCIENCE, 2003, 23 (17) :6826-6836

[3] High Ih channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs [J].

Berger, T ;

Larkum, ME ;

Lüscher, HR .

JOURNAL OF NEUROPHYSIOLOGY, 2001, 85 (02) :855-868

[4] Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion [J].

Bräuer, AU ;

Savaskan, NE ;

Kole, MHP ;

Plaschke, M ;

Monteggia, LM ;

Nestler, EJ ;

Simbürger, E ;

Deisz, RA ;

Ninnemann, O ;

Nitsch, R .

FASEB JOURNAL, 2001, 15 (14) :2689-2701

[5] Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner [J].

Brewster, A ;

Bender, RA ;

Chen, YC ;

Dube, C ;

Eghbal-Ahmadi, M ;

Baram, TZ .

JOURNAL OF NEUROSCIENCE, 2002, 22 (11) :4591-4599

[6] VOLTAGE-CLAMP INVESTIGATIONS OF MEMBRANE CURRENTS UNDERLYING PACE-MAKER ACTIVITY IN RABBIT SINO-ATRIAL NODE [J].

BROWN, H ;

DIFRANCESCO, D .

JOURNAL OF PHYSIOLOGY-LONDON, 1980, 308 (NOV) :331-351

[7] HOW DOES ADRENALINE ACCELERATE THE HEART [J].

BROWN, HF ;

DIFRANCESCO, D ;

NOBLE, SJ .

NATURE, 1979, 280 (5719) :235-236

[8] Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability [J].

Chen, K ;

Aradi, I ;

Thon, N ;

Eghbal-Ahmadi, M ;

Baram, TZ ;

Soltesz, I .

NATURE MEDICINE, 2001, 7 (03) :331-337

[9] Not so funny anymore: Pacing channels are cloned [J].

Clapham, DE .

NEURON, 1998, 21 (01) :5-7

[10]

DIFRANCESCO D, 1993, ANNU REV PHYSIOL, V55, P455, DOI 10.1146/annurev.physiol.55.1.455

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