Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

被引：229

作者：

Garcia-Caceres, Cristina ^{[1
]}

Balland, Eglantine ^{[2
]}

Prevot, Vincent ^{[3
]}

Luquet, Serge ^{[4
]}

Woods, Stephen C. ^{[5
]}

Koch, Marco ^{[6
]}

Horvath, Tamas L. ^{[7
]}

Yi, Chun-Xia ^{[8
]}

Chowen, Julia A. ^{[9
,10
,11
]}

Verkhratsky, Alexei ^{[12
,13
]}

Araque, Alfonso ^{[14
]}

Bechmann, Ingo ^{[6
]}

Tschoep, Matthias H. ^{[1
,15
]}

机构：

[1] German Res Ctr Environm Hlth GmbH, Inst Diabet & Obes, Helmholtz Diabet Ctr, Helmholtz Zentrum Munchen, Neuherberg, Germany

[2] Monash Univ, Biomed Discovery Inst, Dept Physiol, Clayton, Vic, Australia

[3] Univ Lille, Fac Med, Lab Dev & Plast Neuroendocrine Brain, Inserm,Ctr Rech Jean Pierre Aubert, Lille, France

[4] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France

[5] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA

[6] Univ Leipzig, Inst Anat, Leipzig, Germany

[7] Yale Univ, Dept Comparat Med, Sch Med, New Haven, CT USA

[8] Acad Med Ctr Amsterdam, Dept Endocrinol & Metab, Amsterdam, Netherlands

[9] Hosp Infantil Univ Nino Jesus, Dept Endocrinol, Inst Invest Princesa, Madrid, Spain

[10] CEI UAM CSIC, IMDEA Food Inst, Madrid, Spain

[11] Inst Carlos III Madrid, CIBEROBN, Madrid, Spain

[12] Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs, England

[13] Ikerbasque, Basque Fdn Sci, Achucarro Ctr Neurosci, Bilbao, Spain

[14] Univ Minnesota, Dept Neurosci, Minneapolis, MN USA

[15] Tech Univ, Dept Med, Div Metab Dis, Munich, Germany

来源：

NATURE NEUROSCIENCE | 2019年 / 22卷 / 01期

基金：

欧洲研究理事会;

关键词：

GOMORI-POSITIVE ASTROCYTES; BETA/NF-KAPPA-B; AGRP-NEURONS; BODY-WEIGHT; FOOD-INTAKE; ARCUATE NUCLEUS; POMC NEURONS; HYPOCRETIN OREXIN; NEURAL CIRCUITS; NEUROPEPTIDE-Y;

D O I：

10.1038/s41593-018-0286-y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic feeding circuits. These non-neuronal cells are crucial in determining the functional interactions of specific neuronal subpopulations involved in the control of metabolism. Recent advances in biology, optics, genetics, and pharmacology have resulted in the emergence of novel and highly sophisticated approaches for studying hypothalamic neuronal-glial networks. Here we summarize the progress in the field and argue that glial-neuronal interactions provide a core hub integrating food-related cues, interoceptive signals, and internal states to adapt a complex set of physiological responses operating on different timescales to finely tune behavior and metabolism according to metabolic status. This expanding knowledge helps to redefine our understanding of the physiology of food intake and energy metabolism.

引用

页码：7 / 14

页数：8

共 118 条

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