Cardiac troponin I release and cytokine response during experimental human endotoxaemia

被引：25

作者：

van Bockel, EAP ^{[1
]}

Tulleken, JE ^{[1
]}

Kobold, ACM ^{[1
]}

Ligtenberg, JJM ^{[1
]}

van der Werf, TS ^{[1
]}

Spanjersberg, R ^{[1
]}

Zijlstra, JG ^{[1
]}

机构：

[1] Univ Groningen Hosp, Dept Internal Med, Intens & Resp Care Unit, NL-9700 RB Groningen, Netherlands

来源：

INTENSIVE CARE MEDICINE | 2003年 / 29卷 / 09期

关键词：

endotoxin; troponin I; myocardial dysfunction; tumour necrosis factor-alpha (TNF-alpha); interleukin-6 (IL-6); interleukin-8 (IL-8); sepsis;

D O I：

10.1007/s00134-003-1893-x

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Objective. To study the relationship between cytokine levels and cardiac troponin I (cTnI). Design. Prospective experimental study. Setting. Intensive care unit of a university hospital. Participants. Six healthy male volunteers. Interventions. Endotoxin, 4 ng/kg, was given as a 1-min intravenous infusion. Measurements and results. Circulating cardiac troponin I levels and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were analysed at various time points during a 24-h period. TNF-alpha appeared in the circulation 30 min after injection (T=0.5 h), reaching peak levels (5,665+/-1,910 pg/ml) 2 h after infusion. At T=24 h TNF-alpha was still elevated in the circulation compared to T=0. None of the six volunteers had a cTnI value higher than 0.1 mug/l at T=0, 6 h or 24 h. Conclusion. The presence of significant amounts of TNF-alpha, IL-6 and IL-8 in the systemic circulation does not lead to increased levels of cTnI in experimental human endotoxaemia.

引用

页码：1598 / 1600

页数：3

共 14 条

[1] CARDIAC TROPONIN-I - A MARKER WITH HIGH SPECIFICITY FOR CARDIAC INJURY [J].