The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

被引：48

作者：

Al-Karagholi, Mohammad Al-Mahdi ^{[1
]}

Hansen, Jakob Moller ^{[1
]}

Severinsen, Johanne ^{[1
]}

Jansen-Olesen, Inger ^{[1
,2
]}

Ashina, Messoud ^{[1
]}

机构：

[1] Univ Copenhagen, Danish Headache Ctr, Dept Neurol, Rigshosp Glostrup,Fac Hlth & Med Sci, Nordre Ringvej 57, DK-2600 Copenhagen, Denmark

[2] Rigshosp Glostrup, Danish Headache Ctr, Dept Neurol, Glostrup Res Pk, Copenhagen, Denmark

来源：

JOURNAL OF HEADACHE AND PAIN | 2017年 / 18卷

关键词：

Migraine; K-ATP channel; K-ATP channels; Headache; Levcromakalim; Cromakalim; GENE-RELATED PEPTIDE; CYCLASE-ACTIVATING POLYPEPTIDE; NITRIC-OXIDE; POTASSIUM CHANNELS; CEREBRAL-ARTERIES; BLOOD-PRESSURE; ESSENTIAL-HYPERTENSION; VASOMOTOR RESPONSES; IN-VITRO; PINACIDIL;

D O I：

10.1186/s10194-017-0800-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background: To review the distribution and function of K-ATP channels, describe the use of K-ATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine. Discussion: K-ATP channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic K-ATP channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that KATP channel opening may cause headache, possibly due to vascular mechanisms. Whether K-ATP channel openers can provoke migraine in migraine sufferers is not known. Conclusion: We suggest that K-ATP channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.

引用

页数：9

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