Crack whips the heart:: A review of the cardiovascular toxicity of Cocaine

被引：94

作者：

Afonso, Luis ^{[1
]}

Mohammad, Tamam

Thatai, Deepak

机构：

[1] Wayne State Univ, Div Cardiol, Detroit, MI 48202 USA

[2] Wayne State Univ, Div Internal Med, Detroit, MI USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2007年 / 100卷 / 06期

关键词：

D O I：

10.1016/j.amjcard.2007.04.049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cocaine is an extremely powerful reinforcing psychostimulant with highly addictive properties. Over the last few decades, cocaine addiction has attained epidemic proportions in North America, imposing a tremendous burden on society and the health care system. The cardiovascular complications of cocaine abuse are adrenergic mediated and range from cocaine-associated acute coronary syndromes to aortic dissection and sudden cardiac death. Concomitant alcohol and cigarette smoking exacerbate the cardiotoxicity of cocaine. This contemporary review discusses the spectrum of cardiac complications arising from cocaine use, operant pathophysiologic mechanisms and controversies surrounding the pharmacotherapy of cocaine-associated acute coronary syndromes. (c) 2007 Elsevier Inc. All rights reserved.

引用

收藏

页码：1040 / 1043

页数：4

相关论文

共 30 条

[1] UNRECOGNIZED LEFT-VENTRICULAR DYSFUNCTION IN AN APPARENTLY HEALTHY COCAINE ABUSE POPULATION [J].

BERTOLET, BD ;

FREUND, G ;

MARTIN, CA ;

PERCHALSKI, DL ;

WILLIAMS, CM ;

PEPINE, CJ .

CLINICAL CARDIOLOGY, 1990, 13 (05) :323-328

[2] INFLUENCE OF LABETALOL ON COCAINE-INDUCED CORONARY VASOCONSTRICTION IN HUMANS [J].

BOEHRER, JD ;

MOLITERNO, DJ ;

WILLARD, JE ;

HILLIS, LD ;

LANGE, RA .

AMERICAN JOURNAL OF MEDICINE, 1993, 94 (06) :608-610

[3] ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-Segment elevation myocardial infarction - Summary article - A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina) [J].

Braunwald, E ;

Antman, EM ;

Beasley, JW ;

Califf, RM ;

Cheitlin, MD ;

Hochman, JS ;

Jones, RH ;

Kereiakes, D ;

Kupersmith, J ;

Levin, TN ;

Pepine, CJ ;

Schaeffer, JW ;

Smith, EE ;

Steward, DE ;

Theroux, P ;

Gibbons, RJ ;

Alpert, JS ;

Faxon, DP ;

Fuster, V ;

Gregoratos, G ;

Hiratzka, LF ;

Jacobs, AK ;

Smith, SC .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (07) :1366-1374

[4] RECURRENT CORONARY VASOCONSTRICTION CAUSED BY INTRANASAL COCAINE - POSSIBLE ROLE FOR METABOLITES [J].

BROGAN, WC ;

LANGE, RA ;

GLAMANN, DB ;

HILLIS, LD .

ANNALS OF INTERNAL MEDICINE, 1992, 116 (07) :556-561

[5] ALLEVIATION OF COCAINE-INDUCED CORONARY VASOCONSTRICTION BY NITROGLYCERIN [J].

BROGAN, WC ;

LANGE, RA ;

KIM, AS ;

MOLITERNO, DJ ;

HILLIS, LD .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1991, 18 (02) :581-586

[6] COCAINE USE AND THE RISK FOR ENDOCARDITIS IN INTRAVENOUS-DRUG-USERS [J].

CHAMBERS, HF ;

MORRIS, DL ;

TAUBER, MG ;

MODIN, G .

ANNALS OF INTERNAL MEDICINE, 1987, 106 (06) :833-836

[7] RELATION OF ACUTE MYOCARDIAL-INFARCTION TO COCAINE ABUSE [J].

CREGLER, LL ;

MARK, H .

AMERICAN JOURNAL OF CARDIOLOGY, 1985, 56 (12) :794-794

[8] Electrocardiographic findings typical of Brugada syndrome unmasked by cocaine consumption [J].

Daga, B ;

Miñano, A ;

de la Puerta, I ;

Pelegrín, J ;

Rodrigo, G ;

Ferreira, I .

REVISTA ESPANOLA DE CARDIOLOGIA, 2005, 58 (11) :1355-1357

[9] QUANTITATIVE-ANALYSIS OF AMOUNTS OF CORONARY ARTERIAL NARROWING IN COCAINE ADDICTS [J].

DRESSLER, FA ;

MALEKZADEH, S ;

ROBERTS, WC .

AMERICAN JOURNAL OF CARDIOLOGY, 1990, 65 (05) :303-308

[10]

Ferreira S, 2001, J PHARMACOL EXP THER, V299, P220