The genetics of hereditary common cancers

被引：23

作者：

de la Chapelle, A ^{[1
]}

Peltomäki, P

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA

[2] Folkhalsan Inst Genet, Helsinki 00280, Finland

[3] Univ Helsinki, Dept Med Genet, FIN-00290 Helsinki, Finland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0959-437X(98)80085-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Subsets of patients with common cancers belong to families in which the predisposition is inherited in a regular Mendelian fashion. Genes underlying these cancers are now recognized in colorectal cancer (APC, mismatch repair genes, LKB1) and in breast cancer (BRCA1, BRCA2) whereas, in prostate cancer, a locus in chromosome 1 (HPC1) has been proposed on the basis of linkage analysis. Major challenges are to determine the population incidence of these mutations, their penetrance, phenotypic expression, and the effects of modifier genes and epigenetic factors. Finally, the role of encoded proteins in carcinogenesis is a matter of major interest.

引用

页码：298 / 303

页数：6

共 42 条

[1]

Akiyama Y, 1997, CANCER RES, V57, P3920

[2] Recommendations for follow-up care of individuals with an inherited predisposition to cancer .2. BRCA1 and BRCA2 [J].

Burke, W ;

Daly, M ;

Garber, J ;

Botkin, J ;

Kahn, MJE ;

Lynch, P ;

McTierman, A ;

Offit, K ;

Perlman, J ;

Petersen, G ;

Thomson, E ;

Varricchio, C .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (12) :997-1003

[3] Prostate cancer susceptibility locus on chromosome 1q: A confirmatory study [J].

Cooney, KA ;

McCarthy, JD ;

Lange, E ;

Huang, L ;

Miesfeldt, S ;

Montie, JE ;

Oesterling, JE ;

Sandler, HM ;

Lange, K .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (13) :955-959

[4]

COONEY KA, 1997, AM J HUM GENET S, V61, P1583

[5] Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis [J].

Cormier, RT ;

Hong, KH ;

Halberg, RB ;

Hawkins, TL ;

Richardson, P ;

Mulherkar, R ;

Dove, WF ;

Lander, ES .

NATURE GENETICS, 1997, 17 (01) :88-91

[6] BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer [J].

Couch, FJ ;

DeShano, ML ;

Blackwood, MA ;

Calzone, K ;

Stopfer, J ;

Campeau, L ;

Ganguly, A ;

Rebbeck, T ;

Weber, BL ;

Jablon, L ;

Cobleigh, MA ;

Hoskins, K ;

Garber, JE .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (20) :1409-1415

[7]

Dietmaier W, 1997, CANCER RES, V57, P4749

[8] GENETIC IDENTIFICATION OF MOM-1, A MAJOR MODIFIER LOCUS AFFECTING MIN-INDUCED INTESTINAL NEOPLASIA IN THE MOUSE [J].

DIETRICH, WF ;

LANDER, ES ;

SMITH, JS ;

MOSER, AR ;

GOULD, KA ;

LUONGO, C ;

BORENSTEIN, N ;

DOVE, W .

CELL, 1993, 75 (04) :631-639

[9] Mutation in the mismatch repair gene Msh6 causes cancer susceptibility [J].

Edelmann, W ;

Yang, K ;

Umar, A ;

Heyer, J ;

Lau, K ;

Fan, KH ;

Liedtke, W ;

Cohen, PE ;

Kane, MF ;

Lipford, JR ;

Yu, NJ ;

Crouse, GF ;

Pollard, JW ;

Kunkel, T ;

Lipkin, M ;

Kolodner, R ;

Kucherlapati, R .

CELL, 1997, 91 (04) :467-477

[10]

EELES R, 1997, AM J HUM GENET S, V61, P345

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