A study on p16, pRb, cdk4 and cyclinD1 expression in non-small cell lung cancers

被引：39

作者：

Kong, LF ^{[1
]}

Ying, PZ ^{[1
]}

Liu, ZG ^{[1
]}

Gen, JH ^{[1
]}

Zhao, YW ^{[1
]}

机构：

[1] Henan Prov Hosp, Dept Pathol, Zhengzhou 450003, Peoples R China

来源：

CANCER LETTERS | 1998年 / 130卷 / 1-2期

关键词：

p16; pRb; cdk4; cyclinD1; non-small cell lung cancer;

D O I：

10.1016/S0304-3835(98)00115-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To observe the expression of p16, pRb, cdk4 and cyclin D1 in non-small cell lung cancers, 104 cases of resected lung cancers were collected, which included squamous cell carcinomas, adenocarcinomas and large cell carcinomas. Immunohistochemistry assay was carried out. The results showed that 67% of squamous cell carcinomas and 46% of adenocarcinomas expressed p16, 64% of squamous cell carcinomas and 85% of adenocarcinomas expressed pRb and 66% of cancers expressed p16 or pRb. About 70% of the tumors expressed cyclinD1. More than 90% of the tumors expressed cdk4 and there was an increased trend with decreasing differentiation of both squamous cell carcinomas and adenocarcinomas. Sixty-seven percent of the highly differentiated and 100% of the poorly differentiated squamous cell carcinomas expressed cdk4. The aberrant p16 and pRb gene product expression played a significant role in the development and histological subtype of lung cancers by conditioning the biological behavior of NSCLC. cdk4 was an important factor in histological differentiation. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：93 / 101

页数：9

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