Successful use of recombinant factor VIIa (NovoSeven®) during cardiac surgery in a pediatric patient with congenital factor XI deficiency

被引：19

作者：

Avci, Zekai ^{[1
]}

Malbora, Baris ^{[1
]}

Gokdemir, Mahmut ^{[3
]}

Ozkan, Suleyman ^{[2
]}

Ozbek, Namik ^{[1
]}

机构：

[1] Baskent Univ, Fac Med, Dept Pediat Hematol, TR-06490 Ankara, Turkey

[2] Baskent Univ, Fac Med, Dept Cardiovasc Surg, TR-06490 Ankara, Turkey

[3] Baskent Univ, Fac Med, Dept Pediat Cardiol, TR-06490 Ankara, Turkey

来源：

PEDIATRIC CARDIOLOGY | 2008年 / 29卷 / 01期

关键词：

factor XI deficiency; recombinant factor VIIa; heart surgery;

D O I：

10.1007/s00246-007-9081-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report our experience with the use of recombinant activated factor VII (rFVIIa) during cardiac surgery in a 4.5-year-old boy with severe congenital FXI deficiency and a congenital heart disease. After weaning the patient from cardiopulmonary bypass, the first intravenous dose of rFVIIa (90 mu g/kg) was administered. This same dosage was repeated eight more times, at 2- to 4-hour intervals postoperatively. There was no bleeding during and after surgery. rFVIIa treatment may be used successfully in children with severe FXI deficiency in major operations such as open heart surgery.

引用

页码：220 / 222

页数：3

共 15 条

[1] Treatment of factor XI inhibitor using recombinant activated factor VIIa [J].

Bern, MM ;

Sahud, M ;

Zhukov, O ;

Qu, K ;

Mitchell, W .

HAEMOPHILIA, 2005, 11 (01) :20-25

[2] The use of recombinant factor VIIa (NovoSeven®) in a patient with a factor XI deficiency and a circulating anticoagulant [J].

Billon, S ;

Le Niger, C ;

Escoffre-Barbe, M ;

Vicariot, M ;

Abgrall, JF .

BLOOD COAGULATION & FIBRINOLYSIS, 2001, 12 (07) :551-553

[3] What dose of recombinant activated factor VII should be used in patients with factor XI deficiency? [J].

Brown, SA .

HAEMOPHILIA, 2005, 11 (04) :430-431

[4]

FERSTER A, 1993, HAEMOSTASIS, V23, P65

[5]

Hedner U, 1990, Blood Coagul Fibrinolysis, V1, P307, DOI 10.1097/00001721-199008000-00009

[6] Successful use of recombinant factor VIIa in a patient with inhibitor secondary to severe factor XI deficiency [J].

Lawler, P ;

White, B ;

Pye, S ;

Hermans, C ;

Riddell, A ;

Costello, C ;

Brown, S ;

Lee, CA .

HAEMOPHILIA, 2002, 8 (02) :145-148

[7] Factor XI deficiency - from molecular genetics to clinical management [J].

O'Connell, NM .

BLOOD COAGULATION & FIBRINOLYSIS, 2003, 14 :S59-S64

[8]

Pychynska-Pokorska Magdalena, 2004, Pediatr Crit Care Med, V5, P246, DOI 10.1097/01.PCC.0000123546.78900.67

[9] A novel factor XI gene mutation associated with mild factor XI deficiency in a symptomatic patient [J].

Ramadan, Khaled M. ;

McNulty, Orla ;

Anderson, Julia A. M. ;

Jones, Francis G. ;

Winter, Paul C. .

BLOOD COAGULATION & FIBRINOLYSIS, 2006, 17 (06) :499-502

[10] Recombinant factor VIIa (NovoSeven®) as a hemostatic agent after surgery for congenital heart disease [J].

Razon, Y ;

Erez, E ;

Vidne, B ;

Birk, E ;

Katz, J ;

Tamari, H ;

Dagan, O .

PEDIATRIC ANESTHESIA, 2005, 15 (03) :235-240

← 1 2 →