Successful use of recombinant factor VIIa (NovoSeven®) during cardiac surgery in a pediatric patient with congenital factor XI deficiency

被引:19
作者
Avci, Zekai [1 ]
Malbora, Baris [1 ]
Gokdemir, Mahmut [3 ]
Ozkan, Suleyman [2 ]
Ozbek, Namik [1 ]
机构
[1] Baskent Univ, Fac Med, Dept Pediat Hematol, TR-06490 Ankara, Turkey
[2] Baskent Univ, Fac Med, Dept Cardiovasc Surg, TR-06490 Ankara, Turkey
[3] Baskent Univ, Fac Med, Dept Pediat Cardiol, TR-06490 Ankara, Turkey
关键词
factor XI deficiency; recombinant factor VIIa; heart surgery;
D O I
10.1007/s00246-007-9081-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report our experience with the use of recombinant activated factor VII (rFVIIa) during cardiac surgery in a 4.5-year-old boy with severe congenital FXI deficiency and a congenital heart disease. After weaning the patient from cardiopulmonary bypass, the first intravenous dose of rFVIIa (90 mu g/kg) was administered. This same dosage was repeated eight more times, at 2- to 4-hour intervals postoperatively. There was no bleeding during and after surgery. rFVIIa treatment may be used successfully in children with severe FXI deficiency in major operations such as open heart surgery.
引用
收藏
页码:220 / 222
页数:3
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