Therapeutic peptides

被引:185
作者
Lien, S [1 ]
Lowman, HB [1 ]
机构
[1] Genentech Inc, Dept Prot Engn, San Francisco, CA 94080 USA
关键词
D O I
10.1016/j.tibtech.2003.10.005
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Novel peptide therapeutics are increasingly making their way into clinical application. Indeed, certain naturally derived peptides have been successful drugs for many years. With the advent of large biological and synthetic peptide libraries and high-throughput screening, many promising candidates could soon be added to the list of peptides under development. These advances have introduced new strategies for the administration of peptide drugs and improvements of clearance half-lives in vivo. Despite the potential obstacles that remain, peptide therapeutics are poised to play a significant role in the treatment of diseases ranging from Alzheimer's disease to cancer.
引用
收藏
页码:556 / 562
页数:7
相关论文
共 81 条
[1]   Therapeutic cancer targeting peptides [J].
Aina, OH ;
Sroka, TC ;
Chen, ML ;
Lam, KS .
BIOPOLYMERS, 2002, 66 (03) :184-199
[2]   Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].
Arap, W ;
Pasqualini, R ;
Ruoslahti, E .
SCIENCE, 1998, 279 (5349) :377-380
[3]   Steps toward mapping the human vasculature by phage display [J].
Arap, W ;
Kolonin, MG ;
Trepel, M ;
Lahdenranta, J ;
Cardó-Vila, M ;
Giordano, RJ ;
Mintz, PJ ;
Ardelt, PU ;
Yao, VJ ;
Vidal, CI ;
Chen, L ;
Flamm, A ;
Valtanen, H ;
Weavind, LM ;
Hicks, ME ;
Pollock, RE ;
Botz, GH ;
Bucana, CD ;
Koivunen, E ;
Cahill, D ;
Troncoso, P ;
Baggerly, KA ;
Pentz, RD ;
Do, KA ;
Logothetis, CJ ;
Pasqualini, R .
NATURE MEDICINE, 2002, 8 (02) :121-127
[4]   Targeting the prostate for destruction through a vascular address [J].
Arap, W ;
Haedicke, W ;
Bernasconi, M ;
Kain, R ;
Rajotte, D ;
Krajewski, S ;
Ellerby, HM ;
Bredesen, DE ;
Pasqualini, R ;
Ruoslahti, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1527-1531
[5]  
Arap Wadih, 1998, Current Opinion in Oncology, V10, P560, DOI 10.1097/00001622-199811000-00014
[6]   Cloning, expression, genomic localization, and enzymatic activities of the mouse homolog of prostate-specific membrane antigen/NAALADase/folate hydrolase [J].
Bacich, DJ ;
Pinto, JT ;
Tong, WP ;
Heston, WDW .
MAMMALIAN GENOME, 2001, 12 (02) :117-123
[7]   Radio-labeled receptor-binding peptides: A new class of radiopharmaceuticals [J].
Boerman, OC ;
Oyen, WJG ;
Corstens, FHM .
SEMINARS IN NUCLEAR MEDICINE, 2000, 30 (03) :195-208
[8]   Receptor-mediated targeting of spray-dried lipid particles coformulated with immunoglobulin and loaded with a prototype vaccine [J].
Bot, AI ;
Smith, DJ ;
Bot, S ;
Dellamary, L ;
Tarara, TE ;
Harders, S ;
Phillips, W ;
Weers, JG ;
Woods, CM .
PHARMACEUTICAL RESEARCH, 2001, 18 (07) :971-979
[9]   Effect of sonication parameters on transdermal delivery of insulin to hairless rats [J].
Boucaud, A ;
Garrigue, MA ;
Machet, L ;
Vaillant, L ;
Patat, F .
JOURNAL OF CONTROLLED RELEASE, 2002, 81 (1-2) :113-119
[10]   A novel approach for the identification of unique tumor vasculature binding peptides using an E-coli peptide display library [J].
Brown, CK ;
Modzelewski, RA ;
Johnson, CS ;
Wong, MKK .
ANNALS OF SURGICAL ONCOLOGY, 2000, 7 (10) :743-749