Non-transferrin-bound iron during allogeneic stem cell transplantation

被引：120

作者：

Sahlstedt, L

Ebeling, F

von Bonsdorff, L

Parkkinen, J

Ruutu, T

机构：

[1] Univ Helsinki, Cent Hosp, Dept Med, FIN-00029 Helsinki, Finland

[2] Finnish Red Cross, Blood Transfus Serv, Helsinki, Finland

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 113卷 / 03期

关键词：

NTBI; iron; transferrin saturation; stem cell transplantation; bleomycin-detectable iron;

D O I：

10.1046/j.1365-2141.2001.02820.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hydroxyl radical formation catalysed by non-transferrin-bound iron (NTBI) might contribute to transplantation-related complications. The occurrence of NTBI in 10 adult allogeneic stem cell transplantation (SCT) patients was followed for 20 d. The transferrin saturation reached 99% on d -4 and remained >80% thereafter. NTBI, measured as bleomycin-detectable iron, was detected for 6-18 d in all patients with a peak on d -4. High transferrin saturation levels were associated with the appearance of NTBI with a threshold at 80% saturation. Prevention of the potential deleterious effects of NTBI might reduce transplantation-related morbidity.

引用

收藏

页码：836 / 838

页数：3

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