Future perspectives of articular cartilage repair

被引：16

作者：

Gaissmaier, Christoph ^{[1
]}

Koh, Jason L. ^{[2
]}

Weise, Kuno ^{[1
]}

Mollenhauer, Juergen A. ^{[3
,4
]}

机构：

[1] Univ Tubingen, BG Trauma Ctr, D-72076 Tubingen, Germany

[2] Northwestern Univ, Feinberg Sch Med, Dept Orthopaed Surg, Chicago, IL USA

[3] Univ Tubingen, Nat & Med Sci Inst NMI, D-72074 Tubingen, Germany

[4] Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA

来源：

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 2008年 / 39卷

关键词：

cartilage; chondrocytes; tissue engineering; regenerative medicine; legal regulations;

D O I：

10.1016/j.injury.2008.01.033

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Extrapolating from the current state of the art in cartilage repair technology and basic science, we describe the future of regenerative medicine in the musculoskeletal system. Crucial milestones that have been recognised include supply with competent cells from autologous to xenogeneic sources, "intelligent" or "reactive" scaffold design, optimised application of humoral factors and the introduction of advanced gene-engineering technology. Besides these technical goals, ethical and legal considerations may significantly change the way pharmacological and medical components are recruited and regulated. At the same time, governmental regulatory bodies will have to accept new realities such as the existence of adaptive medical devices and of biological combination -implants that are anywhere between a drug and a transplanted organ. For cartilage replacement itself, optimism seems to be justified regarding major advances within the next decade.

引用

页码：S114 / S120

页数：7

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