Should all trials have a Data Safety and Monitoring Committee?

[1] A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST) [J]. AMERICAN HEART JOURNAL, 1997, 134 (01) : 44 - 54

[2] Frasure-Smith N, 1994, JAMA-J AM MED ASSOC, V271, P1080

[3] DEPRESSION FOLLOWING MYOCARDIAL-INFARCTION - IMPACT ON 6-MONTH SURVIVAL [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (15): : 1819 - 1825

[4] POLICIES FOR STUDY MONITORING AND INTERIM REPORTING OF RESULTS [J]. JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (09) : 1477 - 1484

[5] EARLY METHODOLOGICAL DEVELOPMENTS FOR CLINICAL-TRIALS AT THE NATIONAL-HEART-LUNG-AND-BLOOD-INSTITUTE [J]. STATISTICS IN MEDICINE, 1990, 9 (08) : 881 - 892

[6] HILTS PJ, 2000, NY TIMES 0504, pA20

[7] MEINERT CL, 1970, DIABETES, V19, P789

[8] NELSON D, 2000, WASH POST 0302, pA8

[9] *OFF INSP GEN, 1998, PUBL

[10] *US FDA DEP HHS, 2000, GUID I REV BOARDS CL

[1] A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST) [J]. AMERICAN HEART JOURNAL, 1997, 134 (01) : 44 - 54

[2] Frasure-Smith N, 1994, JAMA-J AM MED ASSOC, V271, P1080

[3] DEPRESSION FOLLOWING MYOCARDIAL-INFARCTION - IMPACT ON 6-MONTH SURVIVAL [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (15): : 1819 - 1825

[4] POLICIES FOR STUDY MONITORING AND INTERIM REPORTING OF RESULTS [J]. JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (09) : 1477 - 1484

[5] EARLY METHODOLOGICAL DEVELOPMENTS FOR CLINICAL-TRIALS AT THE NATIONAL-HEART-LUNG-AND-BLOOD-INSTITUTE [J]. STATISTICS IN MEDICINE, 1990, 9 (08) : 881 - 892

[6] HILTS PJ, 2000, NY TIMES 0504, pA20

[7] MEINERT CL, 1970, DIABETES, V19, P789

[8] NELSON D, 2000, WASH POST 0302, pA8

[9] *OFF INSP GEN, 1998, PUBL

[10] *US FDA DEP HHS, 2000, GUID I REV BOARDS CL