4-methylthioamphetamine-induced hyperthermia in mice: influence of serotonergic and catecholaminergic pathways

被引:14
作者
Carmo, H
Remiao, F
Carvalho, F
Fernandes, E
de Boer, D
dos Reys, LA
Bastos, MD
机构
[1] Univ Porto, Fac Pharm, Dept Toxicol, ICETA CEQUP, P-4050047 Oporto, Portugal
[2] Lisbon Sports Med Ctr, Lab Doping Control, Lisbon, Portugal
关键词
4-methylthioamphetamine; hyperthermia; mice; amphetamine derivatives;
D O I
10.1016/S0041-008X(03)00190-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
4-Methylthioamphetamine (4-MTA), also known as p-methylthioamphetamine, is a new amphetamine derivative which in humans has been increasingly associated with severe intoxications and several deaths. As hyperthermia is considered to be one of the most life-threatening acute physiological consequences of amphetamine-related intoxications, it was our aim to determine whether 4-MTA induces changes in body temperature in a mouse model. Accordingly, we measured the subcutaneous temperature after acute administration of 4-MTA in CD1 mice. Because hyperthermia seems to result from the central and peripheral actions of catecholamines and serotonin (5-hydroxytriptamine or 5-HT), we also investigated the possible interactions of some catecholaminergic and serotonergic receptor blockers and the inhibition of monoamine oxidase (MAO) with this effect. 4-MTA induced hyperthermia in CD1 mice. Blockade of the 5-HT receptors with methysergide and MAO inhibition with pargyline resulted in the potentiation of the 4-MTA-induced hyperthermic effect. Blockade of the alpha(1)-adrenergic receptors with prazosin completely reverted the 4-MTA-induced hyperthermia while with the beta-adrenergic receptor blocker dl-propranolol this reversal was not complete. Blockade of the alpha(1)-adrenergic receptors with yohimbine had no effect on the hyperthermia induced by 4-MTA. These results suggest that 4-MTA-induced hyperthermia is highly influenced by the catecholaminergic and serotonergic receptor activation and the MAO activity. (C) 2003 Elsevier science (USA). All rights reserved.
引用
收藏
页码:262 / 271
页数:10
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