Involvement of MyoD and c-myb in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene

被引：15

作者：

Jin, Wei ^{[1
]}

Liu, Yang ^{[2
]}

Chen, Li ^{[1
]}

Zhu, Hua ^{[3
]}

Di, Gen-hong ^{[1
]}

Ling, Hong ^{[1
]}

Wu, Jiong ^{[1
]}

Shao, Zhi-ming ^{[1
]}

机构：

[1] Fudan Univ, Dept Breast Surg, Shanghai Med Coll, Breast Canc Inst,Canc Hosp,Canc Inst,Dept Oncol, Shanghai 200032, Peoples R China

[2] Liaoning Normal Univ, Sch Life Sci, Dalian 116029, Peoples R China

[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Canc Inst New Jersey, New Brunswick, NJ 08903 USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2011年 / 125卷 / 03期

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

MyoD; c-myb; BRCA1; promoter; Histone acetylation; CANCER-CELLS; DNA-BINDING; EXPRESSION; BREAST; METHYLATION; P300; PROMOTER; P53; IDENTIFICATION; ACTIVATION;

D O I：

10.1007/s10549-010-0876-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BRCA1 is closely related to the pathogenesis of breast cancer, BRCA1 mRNA is reduced in sporadic breast cancer cells despite the lack of mutations. In the present report, we find that MyoD expression and BRCA1 expression is correlated in sporadic breast tumors, overexpression of MyoD and c-myb stimulates BRCA1 expression, knockdown of MyoD and c-myb attenuates BRCA1 expression and attenuates the ability of BRCA1 to protect cells against hydrogen peroxide. MyoD and c-myb interact with p300 and PCAF, forming activating transcriptional complexes which bind to E-box and c-myb sites on the BRCA1 promoter and activate its transcription by inducing histone acetylation. Regulation of BRCA1 expression by MyoD and c-myb complexes may be part of an integral signaling pathway that determines and explains breast cancer susceptibility. Detection expression status of the various proteins in these complexes may predispose to the onset of sporadic breast cancer.

引用

页码：699 / 713

页数：15

共 35 条

[1] BRCA1 induces antioxidant gene expression and resistance to oxidative stress [J].