Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guerin over-producing three putative protective antigen candidates

被引：17

作者：

Ohara, N

Matsuoka, M

Nomaguchi, H

Naito, M

Yamada, T

机构：

[1] Nagasaki Univ, Sch Dent, Nagasaki 8528588, Japan

[2] Natl Inst Infect Dis, Leprosy Res Ctr, Tokyo 1890002, Japan

来源：

VACCINE | 2001年 / 19卷 / 15-16期

关键词：

leprosy; BCG; vaccine; recombinant; Ag85;

D O I：

10.1016/S0264-410X(00)00439-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant Mycobacterium boris Bacillus Calmette-Guerin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than five times higher than parental BCG. Immunization of C57BL/6 and BALB/c mice with this rBCG reduced the multiplication of Mycobacterium leprae in the foot pads of both strains of mice. The inhibition by rBCG/BA51 was more evident than that by parental BCG. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1906 / 1910

页数：5

共 29 条

[1] IDENTIFICATION OF IMMUNODOMINANT ANTIGENS DURING INFECTION WITH MYCOBACTERIUM-TUBERCULOSIS [J].