Double-Carbapenem Therapy for Carbapenemase-Producing Klebsiella pneumoniae

被引：181

作者：

Bulik, Catharine C.

Nicolau, David P. ^{[1
,2
]}

机构：

[1] Hartford Hosp, Ctr Antiinfect Res & Dev, FIDSA, FCCP, Hartford, CT 06102 USA

[2] Hartford Hosp, Div Infect Dis, Hartford, CT 06102 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 06期

关键词：

PROLONGED-INFUSION; MEROPENEM; RESISTANCE; PROGRAM; MODEL;

D O I：

10.1128/AAC.01420-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

The limited treatment options available for carbapenemase-producing Klebsiella pneumoniae (KPC) have made it a formidable pathogen. Previously we have shown the enhanced activity of pharmacodynamically optimized doripenem against KPC. Capitalizing on KPC's increased affinity for ertapenem, we evaluated the efficacy of a combination of ertapenem and doripenem in both an in vitro chemostat and an in vivo murine thigh infection model. Overall, the combination of doripenem plus ertapenem demonstrated enhanced efficacy over either agent alone.

引用

收藏

页码：3002 / 3004

页数：3

相关论文

共 12 条

[1]

Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobactetiaceae [J].

Anderson, K. F. ;

Lonsway, D. R. ;

Rasheed, J. K. ;

Biddle, J. ;

Jensen, B. ;

McDougal, L. K. ;

Carey, R. B. ;

Thompson, A. ;

Stocker, S. ;

Limbago, B. ;

Patel, J. B. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (08) :2723-2725

[2]

In Vivo Efficacy of Simulated Human Dosing Regimens of Prolonged-Infusion Doripenem against Carbapenemase-Producing Klebsiella pneumoniae [J].

Bulik, Catharine C. ;

Nicolau, David P. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (10) :4112-4115

[3]

Comparison of the Activity of a Human Simulated, High-Dose, Prolonged Infusion of Meropenem against Klebsiella pneumoniae Producing the KPC Carbapenemase versus That against Pseudomonas aeruginosa in an In Vitro Pharmacodynamic Model [J].

Bulik, Catharine C. ;

Christensen, Henry ;

Li, Peng ;

Sutherland, Christina A. ;

Nicolau, David P. ;

Kuti, Joseph L. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (02) :804-810

[4]

Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-β-lactamase-producing enterobactefiaceae:: Report from the SENTRY antimicrobial surveillance program [J].

Castanheira, Mariana ;

Sader, Helio S. ;

Deshpande, Lalitagauri M. ;

Fritsche, Thomas R. ;

Jones, Ronald N. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (02) :570-573

[5]

CLSI, 2008, METH DIL ANT SUSC TE, VEighth, pM07

[6]

In Vivo Efficacy of 1-and 2-Gram Human Simulated Prolonged Infusions of Doripenem against Pseudomonas aeruginosa [J].

Crandon, Jared L. ;

Bulik, Catharine C. ;

Nicolau, David P. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (10) :4352-4356

[7]

Bactericidal activities of meropenem and ertapenem against extended-spectrum-β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a neutropenic mouse thigh model [J].

DeRyke, C. Andrew ;

Banevicius, Mary Anne ;

Fan, Hong Wei ;

Nicolau, David P. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (04) :1481-1486

[8]

HOLMBERG SD, 1987, REV INFECT DIS, V9, P1065

[9]

Carbapenem Resistance Among Klebsiella pneumoniae Isolates: Risk Factors, Molecular Characteristics, and Susceptibility Patterns [J].

Hussein, Khetam ;

Sprecher, Hanna ;

Mashiach, Tania ;

Oren, Ilana ;

Kassis, Imad ;

Finkelstein, Renato .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2009, 30 (07) :666-671

[10]

Hospital outbreak caused by Klebsiella pneumoniae producing KPC-2 β-lactamase resistant to colistin [J].

Kontopoulou, K. ;

Protonotariou, E. ;

Vasilakos, K. ;

Kriti, M. ;

Koteli, A. ;

Antoniadou, E. ;

Sofianou, D. .

JOURNAL OF HOSPITAL INFECTION, 2010, 76 (01) :70-73