Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum

被引：24

作者：

Barthel, Diana ^{[1
]}

Schlitzer, Martin ^{[2
]}

Pradel, Gabriele ^{[1
]}

机构：

[1] Univ Wurzburg, Res Ctr Infect Dis, D-97070 Wurzburg, Germany

[2] Univ Marburg, Dept Pharmaceut Chem, D-35032 Marburg, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 02期

关键词：

D O I：

10.1128/AAC.00892-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Antibacterial agents are used in malaria therapy due to their effect on two prokaryote organelles, the mitochondrion and the apicoplast. We demonstrate here that the ribosome-blocking antibiotics telithromycin and quinupristin-dalfopristin, but not linezolid, inhibit the growth of Plasmodium falciparum. Both drugs induce delayed death in the parasite, suggesting that their effect involves the impairment of apicoplast translation processes.

引用

页码：774 / 777

页数：4

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