Two cases of subcutaneous Scedosporium apiospermum infection treated with voriconazole

被引：23

作者：

Bosma, F

Voss, A

van Hamersvelt, HW

de Sévaux, RGL

Biert, J

Kullberg, BJ

Melchers, WGJ

Verweij, PE

机构：

[1] Univ Med Ctr Nijmegen, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands

[2] Univ Med Ctr Nijmegen, Dept Nephrol, NL-6500 HB Nijmegen, Netherlands

[3] Univ Med Ctr Nijmegen, Dept Surg, NL-6500 HB Nijmegen, Netherlands

[4] Univ Med Ctr Nijmegen, Dept Med, NL-6500 HB Nijmegen, Netherlands

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2003年 / 9卷 / 07期

关键词：

Scedosporium apiospermum; fingerprinting; voriconazole;

D O I：

10.1046/j.1469-0691.2003.00596.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Scedosporium apiospermum is a mold that is increasingly being recognized as an opportunistic pathogen in immunocompromised patients, and treatment is complicated by intrinsic resistance to several antifungal agents. In our hospital, two cases of S. apiospermum infection occurring within 2 weeks were successfully treated with voriconazole. Since both patients were infected with an uncommon pathogen, a search for a common nosocomial source was performed. As environmental cultures yielded no S. apiospermum , and random amplified polymorphic DNA (RAPD) fingerprinting showed that the patients' strains were genotypically unrelated, we considered a common nosocomial source of S. apiospermum to be unlikely.

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收藏

页码：750 / 753

页数：4

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