Generation of auto-antibodies towards Alzheimer's disease vaccination

被引：43

作者：

Frenkel, D

Kariv, N

Solomon, B ^{[1
]}

机构：

[1] Tel Aviv Univ, Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

来源：

VACCINE | 2001年 / 19卷 / 17-19期

关键词：

Alzheimer's disease; EFRH phage; vaccination;

D O I：

10.1016/S0264-410X(00)00501-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We developed a novel procedure to evoke anti-aggregating beta -amyloid (AP) antibodies, using filamentous phages displaying only Four amino acids EFRH of the beta -amyloid peptide (ABP). This epitope was Found to be the main regulatory site for fibril Formation. For the first time, effective auto-antibodies have been obtained in guinea-pigs. which exhibit human identity in the A betaP. Immunization through a phage-carrying epitope was Found to be long-lasting, and no toxic effect caused by autoimmune response was detected in the challenged animal sections. These antibodies performed similarly to site-directed monoclonal antibodies and to antibodies raised against fibrillar A beta in disaggregation of plaques, and may serve as the basis for developing an anti-A beta vaccine. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2615 / 2619

页数：5

共 12 条

[1] N-terminal EFRH sequence of Alzheimer's β-amyloid peptide represents the epitope of its anti-aggregating antibodies [J].