Norepinephrine transmitter metabolite is a selective cell death messenger in differentiated rat pheochromocytoma cells

被引：27

作者：

Burke, WJ

Schmitt, CA

Gillespie, KN

Li, SW

机构：

[1] VET AFFAIRS MED CTR, ST LOUIS, MO USA

[2] ST LOUIS UNIV, SCH MED, DEPT MED, ST LOUIS, MO 63104 USA

[3] VET AFFAIRS MED CTR, DEPT MED, ST LOUIS, MO USA

[4] ST LOUIS UNIV, SCH MED, DEPT ANAT, ST LOUIS, MO USA

[5] VET AFFAIRS MED CTR, DEPT ANAT, ST LOUIS, MO USA

[6] ST LOUIS UNIV, SCH MED, SCH PUBL HLTH, ST LOUIS, MO USA

来源：

BRAIN RESEARCH | 1996年 / 722卷 / 1-2期

关键词：

3,4-dihydroxyphenylglycolaldehyde; neurotoxin; catecholamine; MAO-A metabolite; PC-12; cell;

D O I：

10.1016/0006-8993(96)00129-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

3,4-Dihydroxyphenylglycoaldehyde (DOPEGAL) is the monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE) and epinephrine (Epi). Oxidative metabolites of amines are predicted toxins. In this study we determine the toxicity of DOPEGAL, its tautomer 2',3,4-trihydroxyacetophenone (THAP) as well as NE, Epi and their oxidative and methylated metabolites in cultures of differentiated PC-12 cells. At 59.5 mu M DOPEGAL, THAP and Epi, but not NE or other NE or Epi metabolites decreased PC-12 cells by 43.8%, 26.7% and 16.8% respectively. DOPEGAL toxicity was concentration and time dependent. Possible implications for degenerative diseases are discussed.

引用

页码：232 / 235

页数：4

共 24 条

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