Absolute risk of breast cancer in women at increased risk: a more useful clinical measure than relative risk?

被引:17
作者
Pharoah, PDP
Mackay, J
机构
[1] Univ Cambridge, Dept Community Med, Strangeways Res Labs, Cambridge CB1 4RN, England
[2] Univ Cambridge, Addenbrookes Hosp, Dept Clin Oncol, Cambridge, England
关键词
D O I
10.1016/S0960-9776(98)90091-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Clinicians involved in the care of women with breast cancer often have to counsel unaffected women who believe themselves to be at increased risk of breast cancer, usually because of a positive family history. Effective counselling requires both qualitative and quantitative descriptions of risk, with the most appropriate quantitative measure being absolute risk. The commonest quantitative measure of risk in the epidemiological literature is relative risk, and an estimation of absolute risk from relative risk is not straightforward. in order to aid clinicians in risk assessment, we have calculated the absolute risk of developing breast cancer for women at varying relative risks and presented the results in a graphical format which should be easy to use in a clinical setting.
引用
收藏
页码:255 / 259
页数:5
相关论文
共 13 条
  • [1] Beral V, 1997, LANCET, V350, P1047, DOI 10.1016/S0140-6736(97)08233-0
  • [2] BENIGN BREAST DISEASES, CARCINOMA IN-SITU, AND BREAST-CANCER RISK
    BODIAN, CA
    [J]. EPIDEMIOLOGIC REVIEWS, 1993, 15 (01) : 177 - 187
  • [3] Calle EE, 1996, LANCET, V347, P1713, DOI 10.1016/S0140-6736(96)90806-5
  • [4] Chiang CL, 1968, An Introduction to Stochastic Processes in Biostatistics
  • [5] Dupont WD, 1996, CANCER, V77, P2193, DOI 10.1002/(SICI)1097-0142(19960601)77:11<2193::AID-CNCR2>3.3.CO
  • [6] 2-I
  • [7] CONVERTING RELATIVE RISKS TO ABSOLUTE RISKS - A GRAPHICAL APPROACH
    DUPONT, WD
    [J]. STATISTICS IN MEDICINE, 1989, 8 (06) : 641 - 651
  • [8] RISK PERCEPTION AND COMMUNICATION
    FISCHHOFF, B
    BOSTROM, A
    QUADREL, MJ
    [J]. ANNUAL REVIEW OF PUBLIC HEALTH, 1993, 14 : 183 - 203
  • [9] Ford Deborah, 1996, P239
  • [10] HALLOWELL N, 1997, IN PRESS J GENET COU