Unusual P450 reactions in plant secondary metabolism

被引：141

作者：

Mizutani, Masaharu ^{[1
]}

Sato, Fumihiko ^{[2
]}

机构：

[1] Kobe Univ, Grad Sch Agr Sci, Kobe, Hyogo 6578501, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Lab Mol & Cellular Biol Totipotency, Kyoto 6068502, Japan

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2011年 / 507卷 / 01期

关键词：

P450; Plant secondary metabolism; Isoquinoline alkaloids; Oxidative rearrangement; Methylenedioxy bridge; Phenol coupling; COPTIS-JAPONICA CELLS; MOLECULAR-CLONING; ALKALOID BIOSYNTHESIS; AMINO-ACID; 2-HYDROXYISOFLAVANONE SYNTHASE; CYTOCHROME-P450; MONOOXYGENASE; HETEROLOGOUS EXPRESSION; OXIDATIVE REARRANGEMENT; ISOFLAVONE BIOSYNTHESIS; FUNCTIONAL EXPRESSION;

D O I：

10.1016/j.abb.2010.09.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plant cytochromes P450 (P450s) participate in a variety of biochemical pathways to produce a vast diversity of plant natural products. The number of P450 genes in plant genomes is estimated to be up to 1% of the total gene annotations of each plant species, implying that plants are huge sources for various P450-dependent reactions. Plant P450s catalyze a wide variety of monooxygenation/hydroxylation reactions in secondary metabolism, and some of them are involved in unusual reactions such as methylenedioxy-bridge formation, phenol coupling reactions, oxidative rearrangement of carbon skeletons, and oxidative C-C bond cleavage. Here, we summarize unusual P450 reactions in various plant secondary metabolisms, and describe their proposed reaction mechanisms. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：194 / 203

页数：10

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