Loss of the CD56hiCD16- NK cell subset and NK cell interferon-γ production during antiretroviral therapy for HIV-1:: partial recovery by human growth hormone

被引:39
作者
Goodier, MR
Imami, N
Moyle, G
Gazzard, B
Gotch, F
机构
[1] Chelsea & Westminster Hosp, Fac Med, Imperial Coll London, Dept Immunol, London SW10 9NH, England
[2] Chelsea & Westminster Hosp, Dept HIV GU Med, London, England
关键词
AIDS; cytokines; NK cells;
D O I
10.1111/j.1365-2249.2003.02329.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Previous studies have shown that human natural killer (NK) cells are lost from the periphery and are functionally suppressed during HIV-1 infection, and that the administration of highly active antiretroviral therapy (HAART) results in a recovery of NK cell numbers in HIV-1-infected individuals. However, despite this recovery, interleukin (IL)-2 + IL-12-driven interferon (IFN)-gamma production by NK cells has been shown to remain suppressed after HAART. Here we show that the innate immune factor IL-15 in combination with IL-12 is also unable to recover NK cell IFN-gamma production in HAART-treated individuals. Furthermore, we also demonstrate an imbalance in the distribution of CD56(lo)CD16(hi) and CD56(hi)CD16(-) NK subsets after successful HAART, CD56(hi)CD16(-) cells being reduced substantially in HIV-1 patients on HAART. Treatment of patients with combined human growth hormone and antiretroviral therapy resulted in further enhancement in the absolute numbers and the proportion of NK cells in some individuals in the absence of parallel effects on CD4(+) T cells. Furthermore, in these individuals HAART with growth hormone resulted in an enhancement of cytokine-driven NK cell activation and IFN-gamma production compared to the HAART-only baseline.
引用
收藏
页码:470 / 476
页数:7
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