Nicotine administration induced changes in the gonadal functions in male rats

被引:37
作者
Kavitharaj, NK [1 ]
Vijayammal, PL [1 ]
机构
[1] Univ Kerala, Dept Biochem, Thiruvananthapuram 695581, Kerala, India
关键词
nicotine; mecamylamine; testosterone; estradiol; T-3; T-4; follicle-stimulating hormone; lipids;
D O I
10.1159/000028262
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nicotine is reported to have toxic effects on gonadal functions, in addition to its established role in the pathogenesis of atherosclerosis and lung cancer, So nicotine-induced biochemical changes were studied in liver and testes. Chronic administration of nicotine was found to produce enhanced synthesis of cholesterol, triglycerides, phospholipids and free fatty acids in the liver and testes. The activity of the lipogenic enzymes was high in liver but unaltered in testes, The testosterone and estradiol levels in the serum were lower. As the changes brought about by chronic administration of nicotine were counteracted by mecamylamine, a known inhibitor of nicotine, it was proven that nicotine is having a specific gonadotoxic effect.
引用
收藏
页码:2 / 7
页数:6
相关论文
共 20 条
[1]  
ASHAKUMARY L, 1991, J ECOTOXICOL ENV MON, V1, P283
[2]   NICOTINE, COTININE, AND ANABASINE INHIBIT AROMATASE IN HUMAN TROPHOBLAST INVITRO [J].
BARBIERI, RL ;
GOCHBERG, J ;
RYAN, KJ .
JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (06) :1727-1733
[3]   NICOTINE, BUT NOT COTININE, HAS A DIRECT TOXIC EFFECT ON OVARIAN-FUNCTION IN THE IMMATURE GONADOTROPIN-STIMULATED RAT [J].
BLACKBURN, CW ;
PETERSON, CA ;
HALES, HA ;
CARRELL, DT ;
JONES, KP ;
URRY, RL ;
PETERSON, CM .
REPRODUCTIVE TOXICOLOGY, 1994, 8 (04) :325-331
[4]  
DEVI KRD, 1992, INDIAN J EXP BIOL, V30, P214
[5]   EASY COLORIMETRIC MICROMETHOD FOR ROUTINE DETERMINATION OF FREE FATTY-ACIDS IN PLASMA [J].
FALHOLT, K ;
LUND, B ;
FALHOLT, W .
CLINICA CHIMICA ACTA, 1973, 46 (02) :105-111
[6]   PHARMACOLOGIC CHARACTERIZATION OF NICOTINE-INDUCED CONDITIONED PLACE PREFERENCE [J].
FUDALA, PJ ;
TEOH, KW ;
IWAMOTO, ET .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1985, 22 (02) :237-241
[7]  
Helen A., 1996, Journal of Ecobiology, V8, P83
[8]   NICOTINIC CHOLINERGIC AGONISTS INHIBIT ANDROGEN BIOSYNTHESIS BY CULTURED RAT TESTICULAR CELLS [J].
KASSON, BG ;
HSUEH, AJW .
ENDOCRINOLOGY, 1985, 117 (05) :1874-1880
[9]  
LATHA MS, 1993, INDIAN J MED RES-B, V98, P44
[10]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265