Signal transduction via unstructured protein conduits

被引：117

作者：

Dunker, A. Keith ^{[1
]}

Uversky, Vladimir N. ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA

来源：

NATURE CHEMICAL BIOLOGY | 2008年 / 4卷 / 04期

关键词：

D O I：

10.1038/nchembio0408-229

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signaling via phosphorylation-regulated protein-protein interactions often involves flexible or unstructured proteins. Detailed biophysical and computational studies on one such interaction reveal a marvelously intricate, temporally regulated, multistep conduit for signal transduction in the cell cycle.

引用

页码：229 / 230

页数：2

共 13 条

[1] Carella Angelo Michele, 2007, Curr Stem Cell Res Ther, V2, P249, DOI 10.2174/157488807781696276
[2] p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
Chu, Isabel
Sun, Jun
Arnaout, Angel
Kahn, Harriette
Hanna, Wedad
Narod, Steven
Sun, Ping
Tan, Cheng-Keat
Hengst, Ludger
Slingerland, Joyce
[J]. CELL, 2007, 128 (02) : 281 - 294
[3] DUNKER AK, 1998, PAC S BIOCOMPUT, V4, P473
[4] Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27Kip1
Galea, Charles A.
Nourse, Amanda
Wang, Yuefeng
Sivakolundu, Sivashankar G.
Heller, William T.
Kriwacki, Richard W.
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2008, 376 (03) : 827 - 838
[5] Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
Grimmler, Matthias
Wang, Yuefeng
Mund, Thomas
Cilensek, Zoran
Keidel, Eva-Maria
Waddell, M. Brett
Jaekel, Heidelinde
Kullmann, Michael
Kriwacki, Richard W.
Hengst, Ludger
[J]. CELL, 2007, 128 (02) : 269 - 280
[6] The importance of intrinsic disorder for protein phosphorylation
Iakoucheva, LM
Radivojac, P
Brown, CJ
O'Connor, TR
Sikes, JG
Obradovic, Z
Dunker, AK
[J]. NUCLEIC ACIDS RESEARCH, 2004, 32 (03) : 1037 - 1049
[7] Structural studies of p21(Waf1/Cip1/Sdi1) in the free and Cdk2-bound state: Conformational disorder mediates binding diversity
Kriwacki, RW
Hengst, L
Tennant, L
Reed, SI
Wright, PE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) : 11504 - 11509
[8] p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding
Lacy, ER
Filippov, I
Lewis, WS
Otieno, S
Xiao, LM
Weiss, S
Hengst, L
Kriwacki, RW
[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (04) : 358 - 364
[9] Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners
Oldfield, Christopher J.
Meng, Jingwei
Yang, Jack Y.
Yang, Mary Qu
Uversky, Vladimir N.
Dunker, A. Keith
[J]. BMC GENOMICS, 2008, 9 (Suppl 1)
[10] Crystal structure of the p27(Kip1) cyclin-dependent-kinase inhibitor bound to the cyclin A Cdk2 complex
Russo, AA
Jeffrey, PD
Patten, AK
Massague, J
Pavletich, NP
[J]. NATURE, 1996, 382 (6589) : 325 - 331

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