Diffusion tensor imaging in the diagnosis of primary lateral sclerosis

被引:40
作者
Ulug, AM
Grünewald, T
Lin, MT
Kamal, AK
Filippi, CG
Zimmerman, RD
Beal, MF
机构
[1] Cornell Univ, Weill Med Coll, Dept Radiol, New York, NY 10021 USA
[2] Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY USA
关键词
MRI; primary lateral sclerosis; upper motor neuron disease; diffusion tensor imaging; ALS; Babinski sign;
D O I
10.1002/jmri.10433
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To evaluate the utility of MR diffusion tensor imaging in diagnosing primary lateral sclerosis (PLS). Materials and Methods: Five patients who met clinical criteria for a diagnosis of PLS, and two patients with possible PLS of less than three years duration and eight normal volunteers were studied using MR diffusion tensor imaging. Results: All seven patients showed decreased diffusion anisotropy and increased diffusion constant in the PLIC, with complete separation from a normal control group, including patients early in the course of the illness. Conclusion: Quantitative diffusion tensor imaging appears to be a useful test to detect upper motor neuron damage and hence to help to establish the diagnosis of PLS.
引用
收藏
页码:34 / 39
页数:6
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