Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid

被引：158

作者：

Fonseca, T

Gigante, B

Marques, MM

Gilchrist, TL

De Clercq, E

机构：

[1] INETI, Dept Tecnol & Ind Quim, P-1649038 Lisbon, Portugal

[2] Inst Super Tecn, Ctr Quim Estrutural, P-1049001 Lisbon, Portugal

[3] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[4] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 01期

关键词：

diterpenes; resin acids; benzimidazoles; quinoxalines; indoles;

D O I：

10.1016/j.bmc.2003.10.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Several heterocycles, such as benzimidazoles, quinoxalines and indoles incorporated into a hydrophenanthrene and naphthalene skeleton, were synthesised from two useful ortho-bromonitro precursors derived from debydroabietic acid: methyl 12-bromo-13-nitro-deisopropyldehydroabietate and methyl 12-bromo- I 3,14-dinitro-deisopropyidehydroabietate. The new heterocycles were evaluated for their activity in vitro against several RNA and DNA viruses. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：103 / 112

页数：10

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[1]

Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors [J].