TMS studies of preictal cortical excitability change

被引：9

作者：

Richardson, Mark P. ^{[1
]}

da Silva, Fernando H. Lopes ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, London SE5 8AF, England

来源：

EPILEPSY RESEARCH | 2011年 / 97卷 / 03期

关键词：

Epilepsy; TMS; Pre-ictal; TRANSCRANIAL MAGNETIC STIMULATION; TEMPORAL-LOBE EPILEPSY; HUMAN MOTOR CORTEX; CONSCIOUS HUMANS; VOLUNTARY CONTRACTION; DYNAMICAL DISEASES; PYRAMIDAL TRACT; BRAIN SYSTEMS; INHIBITION; TRANSITION;

D O I：

10.1016/j.eplepsyres.2011.10.018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The transition between the interictal and ictal states may be characterised in terms of the dynamics of a complex system. Seizures may emerge because of a change in system parameters, but these parameters may be invisible to passive observation. Therefore, a number of investigators have developed methods to probe the system using stimulation; these probing stimuli may reveal important hidden parameters. Here we describe studies from two sets of investigators working independently, which have shown that motor responses to transcranial magnetic brain stimulation (TMS) differ between the interictal state remote from any seizure, and a period of hours immediately prior to a seizure. We place these studies in the context of the known physiology of motor responses to TMS and discuss how actively probing the state of brain excitability may open new windows on its dynamics. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：273 / 277

页数：5

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