Calorie Restriction: Is AMPK a Key Sensor and Effector?

被引：223

作者：

Canto, Carles ^{[1
]}

Auwerx, Johan

机构：

[1] Ecole Polytech Fed Lausanne, Lab Integrat & Syst Physiol, Lausanne, Switzerland

来源：

PHYSIOLOGY | 2011年 / 26卷 / 04期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

ACTIVATED PROTEIN-KINASE; EXTENDS LIFE-SPAN; FOXO TRANSCRIPTION FACTORS; DIETARY RESTRICTION; SKELETAL-MUSCLE; MITOCHONDRIAL BIOGENESIS; SACCHAROMYCES-CEREVISIAE; DIRECT PHOSPHORYLATION; DEPENDENT REGULATION; GLUCOSE-METABOLISM;

D O I：

10.1152/physiol.00010.2011

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sensor with the ability to transcriptionally reprogram the cell and metabolically adapt to external cues. In this review, we will discuss the possible role of AMPK in the beneficial effects of calorie restriction on health and life span.

引用

页码：214 / 224

页数：11

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