Sterol composition of itraconazole-resistant and itraconazole-susceptible isolates of Aspergillus fumigatus

被引：6

作者：

Dannaoui, E ^{[1
]}

Persat, F ^{[1
]}

Borel, E ^{[1
]}

Piens, MA ^{[1
]}

Picot, S ^{[1
]}

机构：

[1] Univ Lyon 1, Lab Parasitol Mycol Med & Pathol Exot, F-69373 Lyon, France

来源：

CANADIAN JOURNAL OF MICROBIOLOGY | 2001年 / 47卷 / 08期

关键词：

Aspergillus fumigatus; itraconazole resistance; sterol composition;

D O I：

10.1139/cjm-47-8-706

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sterol composition of four clinical isolates of Aspergillus fumigatus resistant to itraconazole was determined by gas chromatography - mass spectrometry and compared with that of four susceptible strains. For all strains, the major sterol was ergosterol. Sterol compositions were qualitatively and quantitatively similar for the resistant and susceptible strains. These results suggest that itraconazole resistance is not related, for the strains studied, to alterations in the ergosterol synthesis pathway.

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页码：706 / 710

页数：5

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