Tissue diagnostics by using fiberoptic FTIR-spectroscopy

被引：5

作者：

Bindig, U ^{[1
]}

Wäsche, W ^{[1
]}

Liebold, K ^{[1
]}

Winter, H ^{[1
]}

Gross, UM ^{[1
]}

Frege, P ^{[1
]}

Müller, G ^{[1
]}

机构：

[1] Laser & Med Technol GGMBH, D-12207 Berlin, Germany

来源：

OPTICAL BIOPSIES AND MICROSCOPIC TECHNIQUES III, PROCEEDINGS OF | 1999年 / 3568卷

关键词：

micro-FTIR-spectroscopy; IR-map; biological tissue; ATR; fiberoptic;

D O I：

10.1117/12.336815

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The infrared spectrum of biological tissue is due to the "microheterogenous'' composition as a whole and is based on complex vibrational modes. In detail, the spectrum represents the biochemical status resulting from a combination of the structural framework of tissues together with the biological active compounds of metabolism. According to the literature, the main IR-spectroscopic differences are to be expected by the characteristic spectral pattern which is located at the 'fingerprint' region (1500 - 1000 cm(-1)). In order to design and develop an endoscopic system for the in vivo identification of healthy and malignant tissue FTIR-measurements were carried out using a fiberoptic device. The source of IR-radiation can be either the FTIR-spectrometer or tunable IR-diode lasers. Fiberoptic IR-spectra obtained using the attenuated total reflectance (ATR) and reflection mode were compared to spectra resulting from the FTIR-microspectroscopic measurements.

引用

页码：38 / 45

页数：8

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