Chiral 1,3-cyclobutane amino acids: Syntheses and extended conformations

被引：31

作者：

Burgess, K

Li, SM

Rebenspies, J

机构：

[1] Department of Chemistry, Texas A and M University, College Station

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 10期

基金：

美国国家卫生研究院;

关键词：

conformationally constrained; cyclobutane; amino acid;

D O I：

10.1016/S0040-4039(97)00200-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active samples of the N-protected 1,3-cyclobutane amino acids 1 and 2 were prepared from alpha-pinene. The synthesis of 1 is enantiodivergent insofar as both optical antipodes of the product can be prepared from the same alpha-pinene enantiomer. Single crystal X-ray diffraction studies of derivatives of 1 reveal these compounds can have extended conformations. (C) 1997 Elsevier Science Ltd.

引用

页码：1681 / 1684

页数：4

共 15 条

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