The neutral theory in the genomic era

被引：63

作者：

Fay, JC

Wu, CI

机构：

[1] Univ Chicago, Comm Genet, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0959-437X(00)00247-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A number of tests have been developed to detect positive selection at the molecular level. These tests are based on DNA polymorphism within and divergence between species. Applications of these tests have revealed a large collection of genes that have evolved under positive selection and some general insights into adaptive evolution. Recently, these tests have been applied on a genomic scale and have provided estimates of the frequency of adaptive substitutions and a critical test of the neutral theory.

引用

页码：642 / 646

页数：5

共 58 条

[1] Within- and between-species DNA sequence variation and the 'footprint' of natural selection [J].