Functional evidence of α1D-adrenoceptors in the vasculature of young and adult spontaneously hypertensive rats

被引：54

作者：

Villalobos-Molina, R ^{[1
]}

López-Guerrero, JJ ^{[1
]}

Ibarra, M ^{[1
]}

机构：

[1] IPN, CINVESTAV, Dept Farmacol & Toxicol, Mexico City 14000, DF, Mexico

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1999年 / 126卷 / 07期

关键词：

alpha(1D)-adrenoceptors; BMY; 7378; pithed spontaneously hypertensive rats; ageing;

D O I：

10.1038/sj.bjp.0702468

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The role of alpha(1D)-adrenoceptors in the vasculature of spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY), of different ages was assessed in pithed rats by the use of the selective alpha(1D)-adrenoceptor antagonist BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro [4.5]decane-7,9-dione dihydrochloride). BMY 7378 displaced the presser effect of phenylephrine in young pre-hypertensive pithed SHR rats, but produced no effect in young WKY rats (dose ratio of 3.4 and 1.6, respectively), while in adult rats BMY 7378 produced a greater shift in the phenylephrine response curve than in younger animals (dose ratio of 3.2 and 6.2 in WKY and SHR, respectively). The presence of alpha(1D)-adrenoceptors in the vasculature of pre-hypertensive rats, suggests its role in the pathogenesis/maintenance of increased blood pressure.

引用

页码：1534 / 1536

页数：3

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