Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction

被引：140

作者：

Guo, Jun

Lin, Guo-sheng

Bao, Cui-yu

Hu, Zhi-min

Hu, Ming-yan

机构：

[1] Wuhan Univ, Sch Med, Renmin Hosp, Dept Cardiol, Wuhan 430060, Peoples R China

[2] Xianning Coll, Cardiovasc Res Inst, Hubei, Peoples R China

[3] First Hosp Wuhan, Dept Dermatol, Wuhan, Peoples R China

来源：

INFLAMMATION | 2007年 / 30卷 / 3-4期

关键词：

stem cells; myocardial infarction; inflammation; remodeling; MARROW STROMAL CELLS; IMPROVES CARDIAC-FUNCTION; MYOBLAST TRANSPLANTATION; GENE-EXPRESSION; CARDIOMYOCYTES; HEART; FUSION; PROLIFERATION; INHIBITOR; COLLAGEN;

D O I：

10.1007/s10753-007-9025-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The aim of the present study was to investigate the role of anti-inflammation for MSCs transplantation in rat models of myocardial infarction. Rats with AMI induced by occlusion of the left coronary artery were randomized to MSCs transplantation group, MI group and sham operated group. The effects of MSCs transplantation on cardiac inflammation and left ventricular remodeling in non-infarcted zone were observed after 4 weeks of MI. We found that MSC transplantation (1) decreased protein production and gene expression of inflammation cytokines TNF-alpha, IL-1 beta and IL-6, (2) inhibited deposition of type I and III collagen, as well as gene and protein expression of MMP-1 and TIMP-1, (3) attenuated LV cavitary dilation and transmural infarct thinning, thus prevent myocardial remodeling after myocardial infarction, and (4) increased EF, FS, LVESP and dp/dtmax (P < 0.01), decreased LVDd, LVEDV, LVEDP (P < 0.05). Anti-inflammation role for MSCs transplantation might partly account for the cardiac protective effect in ischemic heart disease.

引用

页码：97 / 104

页数：8

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