Minimally Invasive and Regenerative Therapeutics

被引：170

作者：

Ashammakhi, Nureddin ^{[1
,2
,3
,4
,5
,6
]}

Ahadian, Samad ^{[1
,2
,3
]}

Darabi, Mohammad Ali ^{[1
,2
,3
]}

El Tahchi, Mario ^{[1
,2
,3
,7
]}

Lee, Junmin ^{[1
,2
,3
]}

Suthiwanich, Kasinan ^{[1
,2
,3
,8
]}

Sheikhi, Amir ^{[1
,2
,3
]}

Dokmeci, Mehmet R. ^{[1
,2
,3
]}

Oklu, Rahmi ^{[9
]}

Khademhosseini, Ali ^{[1
,2
,3
,6
,10
,11
,12
]}

机构：

[1] Univ Calif Los Angeles, Ctr Minimally Invas Therapeut, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Calif NanoSyst Inst CNSI, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[4] Oulu Univ Hosp, Dept Surg, Div Plast Surg, FI-90014 Oulu, Finland

[5] Libyan Author Res Sci & Technol, Biotechnol Res Ctr, Tripoli, Libya

[6] Univ Calif Los Angeles, Dept Radiol Sci, Los Angeles, CA 90095 USA

[7] Lebanese Univ, Fac Sci 2, Dept Phys, LBMI, POB 90656, Jdeidet, Lebanon

[8] Tokyo Inst Technol, Sch Mat & Chem Technol, Dept Mat Sci & Engn, Tokyo 1528552, Japan

[9] Mayo Clin, Dept Radiol, Div Intervent Radiol, Scottsdale, AZ 13400 USA

[10] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA

[11] King Abdulaziz Univ, Dept Phys, Ctr Nanotechnol, Jeddah 21589, Saudi Arabia

[12] Konkuk Univ, Coll Anim Biosci & Technol, Dept Bioind Technol, Seoul 13557, South Korea

来源：

ADVANCED MATERIALS | 2019年 / 31卷 / 01期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

biomaterials; biomolecules; delivery; minimally invasive; scaffolds; tissue regeneration; MESENCHYMAL STEM-CELLS; SPINAL-CORD-INJURY; PLATELET-RICH PLASMA; INTERVERTEBRAL DISC REPAIR; LOW-BACK-PAIN; HUMAN-INDUCED PLURIPOTENT; SHEAR-THINNING HYDROGELS; MARROW STROMAL CELLS; DRUG-DELIVERY; IN-VITRO;

D O I：

10.1002/adma.201804041

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Advances in biomaterial synthesis and fabrication, stem cell biology, bioimaging, microsurgery procedures, and microscale technologies have made minimally invasive therapeutics a viable tool in regenerative medicine. Therapeutics, herein defined as cells, biomaterials, biomolecules, and their combinations, can be delivered in a minimally invasive way to regenerate different tissues in the body, such as bone, cartilage, pancreas, cardiac, skeletal muscle, liver, skin, and neural tissues. Sophisticated methods of tracking, sensing, and stimulation of therapeutics in vivo using nano-biomaterials and soft bioelectronic devices provide great opportunities to further develop minimally invasive and regenerative therapeutics (MIRET). In general, minimally invasive delivery methods offer high yield with low risk of complications and reduced costs compared to conventional delivery methods. Here, minimally invasive approaches for delivering regenerative therapeutics into the body are reviewed. The use of MIRET to treat different tissues and organs is described. Although some clinical trials have been performed using MIRET, it is hoped that such therapeutics find wider applications to treat patients. Finally, some future perspective and challenges for this emerging field are highlighted.

引用

页数：32

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